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Rank #24 ITN Score: 17/30

Loneliness & Social Isolation

Loneliness and social isolation are a widespread, under-recognized driver of premature death and chronic disease, affecting roughly one in six people worldwide. The space lacks dedicated funding and proven scalable interventions.

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Loneliness and social isolation are now recognized by the WHO as a global public health threat operating through cardiovascular, neurological, and mortality pathways. This founding report distinguishes loneliness from mental illness, quantifies its mortality burden, surveys the thin but growing evidence base for interventions, and argues for treating social connection as measurable, fundable health infrastructure.

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