Biological aging is the shared upstream driver of most chronic disease and death, yet directly targeting the aging process — rather than individual diseases — remains scientifically immature with no proven human interventions.
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Aging is the single largest risk factor for the diseases that kill most people, yet medicine treats those diseases one at a time rather than their shared upstream cause. This founding report surveys the biology of aging, the emerging geroscience hypothesis, the scientific and regulatory barriers to translation, and why directly targeting aging could be among the highest-leverage — if hardest — bets in global health.
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